Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.61 |
| ▸ | PPARG | P37231 | 3/20 | 0.58 |
| ▸ | YAP1 | P46937 | 1/20 | 0.57 |
| ▸ | BCL2 | P10415 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.55 |
| ▸ | ACE | P12821 | 2/20 | 0.55 |
| ▸ | MME | P08473 | 1/20 | 0.55 |
| ▸ | CPA1 | P15085 | 1/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.55 |
| ▸ | GPR34 | Q9UPC5 | 5/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160820 | 1.00 | PTPN1 (0.61) | PTPN1PPARGYAP1BCL2ITGB3 | |
| SCHEMBL6165779 | 0.92 | YAP1 (0.58) | PTPN1PPARGYAP1BCL2ITGB3 | |
| SCHEMBL6165785 | 0.92 | YAP1 (0.58) | PTPN1PPARGYAP1BCL2ITGB3 | |
| SCHEMBL6160931 | 0.90 | ACE (0.62) | PPARGITGB3ITGA2BACEMME | |
| SCHEMBL6160926 | 0.90 | ACE (0.62) | PPARGITGB3ITGA2BACEMME | |
| SCHEMBL193473 | 0.89 | PTPN1 (0.73) | PTPN1PPARGYAP1BCL2ITGB3 | |
| SCHEMBL193474 | 0.89 | PTPN1 (0.73) | PTPN1PPARGYAP1BCL2ITGB3 | |
| SCHEMBL2891538 | 0.89 | PTPN1 (0.73) | PTPN1PPARGYAP1BCL2ITGB3 | |
| SCHEMBL8409577 | 0.87 | ACE (0.64) | PTPN1PPARGBCL2ITGB3ITGA2B | |
| SCHEMBL8409581 | 0.87 | ACE (0.64) | PTPN1PPARGBCL2ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |