Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 3/20 | 0.55 |
| ▸ | CTSK | P43235 | 2/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | CTSB | P07858 | 1/20 | 0.55 |
| ▸ | MME | P08473 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160931 | 1.00 | ACE (0.62) | ACENPSR1CTSSCTSKCTSL | |
| SCHEMBL8409581 | 0.94 | ACE (0.64) | ACENPSR1CTSSCTSKCTSL | |
| SCHEMBL8409577 | 0.94 | ACE (0.64) | ACENPSR1CTSSCTSKCTSL | |
| SCHEMBL6160820 | 0.90 | PTPN1 (0.61) | ACEMMEACE2PPARAPPARG | |
| SCHEMBL6160810 | 0.90 | PTPN1 (0.61) | ACEMMEACE2PPARAPPARG | |
| SCHEMBL8698935 | 0.88 | CTSK (0.57) | ACECTSSCTSKCTSLCTSB | |
| SCHEMBL7370522 | 0.88 | CTSK (0.57) | ACECTSSCTSKCTSLCTSB | |
| SCHEMBL5861728 | 0.87 | CTSB (0.60) | ACECTSSCTSKCTSLCTSB | |
| SCHEMBL15576634 | 0.87 | HDAC8 (0.59) | ACECTSSCTSKCTSLCTSB | |
| SCHEMBL9610767 | 0.87 | HDAC8 (0.59) | ACECTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |