Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.76 |
| ▸ | MAPT | P10636 | 6/20 | 0.76 |
| ▸ | HPGD | P15428 | 5/20 | 0.76 |
| ▸ | GAA | P10253 | 5/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | GRM5 | P41594 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159255 | 0.87 | GRM6 (0.78) | GRM6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL14414355 | 0.87 | GRM6 (0.77) | GRM6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL25758961 | 0.86 | GRM6 (0.76) | GRM6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL4217459 | 0.86 | GRM6 (1.00) | GRM6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL7851735 | 0.83 | GRM6 (0.71) | GRM6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL31464161 | 0.83 | GRM6 (0.71) | GRM6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL7207512 | 0.83 | GRM6 (0.71) | GRM6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL6161028 | 0.83 | GRM6 (0.70) | GRM6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL4249297 | 0.82 | GRM6 (0.70) | GRM6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL7825012 | 0.82 | GRM6 (0.69) | GRM6ALDH1A1MAPTHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007102679-A1 | NOVEL THIENOPYRIMIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2007-09-13 | — | — | WO | disclosed |
| US-6849738-B2 | Processes for the production of thienopyrimidine derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-02-01 | — | — | US | disclosed |
| EP-0678577-B1 | Method for the production of recombinant human LH-RH receptor proteins in specific CHO cell lines. | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-09-08 | — | — | EP | disclosed |
| EP-0756599-B1 | BICYCLIC THIOPHENE DERIVATIVES AND USE AS GONADOTROPIN RELEASING HORMONE ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-11-26 | — | — | EP | disclosed |
| EP-0808317-B1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-20030055269-A1 | Processes for the production of thienopyrimidine derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-03-20 | — | — | US | disclosed |
| US-6514988-B1 | A pregnancy controlling agent and a menstrual cycle controlling agent; useful as an agent of spawning promotion in fish | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-02-04 | — | — | US | disclosed |
| US-20020198384-A1 | Thienopyridine derivatives, their intermediates and production thereof | MIKI SHOKYO (JP) | 2002-12-26 | — | — | US | disclosed |
| EP-1266898-A1 | PROCESSES FOR THE PRODUCTION OF THIENOPYRIMIDINE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2002-12-18 | — | — | EP | disclosed |
| EP-0846119-B1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE AS ENDOTHELIN ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-5744479-A | PITUITARY HORMONE INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-28 | — | — | US | disclosed |
| EP-0808317-A1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-11-26 | — | — | EP | disclosed |
| US-5677184-A | GENETIC ENGINEERED CHINESE HAMSTER OVARY CELLS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-14 | — | — | US | disclosed |
| WO-1997014697-A1 | THIENOPYRIDINE DERIVATIVES AS GONADOTROPIN RELEASING HORMONE ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |
| WO-1997007119-A1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-02-27 | — | — | WO | disclosed |
| EP-0756599-A1 | BICYCLIC THIOPHENE DERIVATIVES AND USE AS GONADOTROPIN RELEASING HORMONE ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 1997-02-05 | — | — | EP | disclosed |
| WO-1996024597-A1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-08-15 | — | — | WO | disclosed |
| WO-1995028405-A1 | BICYCLIC THIOPHENE DERIVATIVES AND USE AS GONADOTROPIN RELEASING HORMONE ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-26 | — | — | WO | disclosed |
| EP-0678577-A2 | Method for the production of recombinant human LH-RH receptor proteins | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-25 | — | — | EP | disclosed |
| EP-0640606-A1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198384-A1 | Thienopyridine derivatives, their intermediates and production thereof | GNRHR, KISS1R, CYP19A1 | GRM6 518/4885ALDH1A1 2482/4885MAPT 2641/4885 |
| US-20030055269-A1 | Processes for the production of thienopyrimidine derivatives | GNRHR, NR5A1, DHODH | GRM6 136/4885ALDH1A1 1334/4885MAPT 3360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.