Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 7/20 | 0.71 |
| ▸ | GRM5 | P41594 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159255 | 0.87 | GRM6 (0.78) | GRM6GRM5ALDH1A1HPGDGAA | |
| SCHEMBL27461391 | 0.86 | GRM6 (0.60) | GRM6GRM5ALDH1A1HPGDGAA | |
| SCHEMBL7957161 | 0.84 | GRM6 (0.77) | GRM6GRM5ALDH1A1HPGDGAA | |
| SCHEMBL6160814 | 0.83 | GRM6 (1.00) | GRM6GRM5ALDH1A1HPGDGAA | |
| SCHEMBL6161028 | 0.82 | GRM6 (0.70) | GRM6GRM5ALDH1A1HPGDGAA | |
| SCHEMBL14485422 | 0.80 | PTPN1 (0.53) | GRM6ALDH1A1HPGDGAAMAPT | |
| SCHEMBL12297930 | 0.79 | ALDH1A1 (0.67) | GRM6GRM5ALDH1A1HPGDGAA | |
| SCHEMBL26637734 | 0.78 | GRM6 (0.52) | GRM6GRM5ALDH1A1HPGDGAA | |
| SCHEMBL10714368 | 0.76 | GRM6 (1.00) | GRM6GRM5ALDH1A1HPGDGAA | |
| SCHEMBL6821812 | 0.75 | GRM6 (0.46) | GRM6GRM5ALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808317-B1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-10 | — | — | EP | disclosed |
| CN-1064045-C | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-04-04 | — | — | CN | disclosed |
| CN-1063446-C | Thienopyridine derivatives as gonadotropin releasing hormone antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-03-21 | — | — | CN | disclosed |
| US-6180792-B1 | DRUGS, ANTISECRETORY AGENTS AND HORMONE INHIBITORS FOR LH-RH | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-30 | — | — | US | disclosed |
| US-6048863-A | SEXUAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-04-11 | — | — | US | disclosed |
| US-6015789-A | LUTEINIZING HORMONE RELEASING HORMONE AGONIST AND A LUTEINIZING HORMONE RELEASING HORMONE ANTAGONIST IN COMBINATION, | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-01-18 | — | — | US | disclosed |
| US-5977132-A | GALACTORRHEA, HYPERPROLACTINEMIC OVULATION, PROLACTINOMA AND BRAIN TUMORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0906115-A1 | COMBINED USE OF GnRH AGONIST AND ANTAGONIST | Takeda Chemical Industries, Ltd. (JP) | 1999-04-07 | — | — | EP | disclosed |
| CN-1200124-A | Thienopyridine derivatives as gonadotropin releasing hormone antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-11-25 | — | — | CN | disclosed |
| CN-1173868-A | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-02-18 | — | — | CN | disclosed |
| EP-0808317-A1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-11-26 | — | — | EP | disclosed |
| WO-1997040846-A1 | COMBINED USE OF GnRH AGONIST AND ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-11-06 | — | — | WO | disclosed |
| EP-0781774-A2 | Prolactin production inhibitory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996024597-A1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-08-15 | — | — | WO | disclosed |
| CN-1106663-A | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-08-16 | — | — | CN | disclosed |