Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 3/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160808 | 1.00 | MAPT (0.50) | MAPTALDH1A1KDM4EGAACASP1 | |
| SCHEMBL29404786 | 0.87 | GHSR (0.48) | MAPTALDH1A1KDM4EGAACASP1 | |
| SCHEMBL14979430 | 0.87 | GHSR (0.48) | MAPTALDH1A1KDM4EGAACASP1 | |
| SCHEMBL8711960 | 0.84 | MAPT (0.56) | MAPTALDH1A1KDM4EGAACASP1 | |
| SCHEMBL28676764 | 0.83 | ACE (0.52) | MAPTALDH1A1KDM4EGAACASP1 | |
| SCHEMBL8530675 | 0.83 | ACE (0.52) | MAPTALDH1A1KDM4EGAACASP1 | |
| SCHEMBL27514965 | 0.82 | ACE (0.42) | MAPTALDH1A1KDM4EGAACASP1 | |
| SCHEMBL6160724 | 0.82 | ACE (0.46) | MAPTALDH1A1KDM4EGAACASP1 | |
| SCHEMBL6160719 | 0.82 | ACE (0.46) | MAPTALDH1A1KDM4EGAACASP1 | |
| SCHEMBL3855556 | 0.81 | MAPT (0.58) | MAPTALDH1A1KDM4EGAACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| CN-1143647-A | Dipeptides which promote release of growth hormone | PFIZER (US) | 1997-02-26 | — | — | CN | disclosed |