Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 6/20 | 0.69 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.65 |
| ▸ | CACNB1 | Q02641 | 7/20 | 0.65 |
| ▸ | CACNA1B | Q00975 | 6/20 | 0.65 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.65 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162758 | 0.86 | CACNA1G (0.85) | CACNA1GCACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL3301602 | 0.85 | GPX4 (0.75) | CACNA1GCACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL3954648 | 0.82 | CACNA1G (1.00) | CACNA1GCACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL1377935 | 0.81 | CACNA1G (0.60) | CACNA1GCACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL12150956 | 0.81 | CACNA1G (0.60) | CACNA1GCACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL1374070 | 0.80 | CACNA1G (0.59) | CACNA1GCACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL12431993 | 0.80 | CACNA1G (0.59) | CACNA1GCACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL3962967 | 0.79 | CACNA1G (0.77) | CACNA1GCACNA2D1CACNB1CACNA1BCACNA1C | |
| Z160 SCHEMBL4180792 | 0.79 | CACNA2D1 (1.00) | CACNA1GCACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4778556 | 0.79 | CACNA2D1 (0.72) | CACNA1GCACNA2D1CACNB1CACNA1BCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060163-B1 | NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES | KLINGE CO CHEM PHARM FAB (DE) | 2005-10-12 | — | — | EP | disclosed |
| US-6903118-B1 | Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides | KLINGE PHARMA GMBH (DE) | 2005-06-07 | — | — | US | disclosed |
| EP-1060163-A1 | NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES | Klinge Pharma GmbH (DE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999031063-A1 | NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |