Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC2 | Q13490 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160534 | 0.92 | ALDH1A1 (0.44) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL6161299 | 0.92 | ALDH1A1 (0.44) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL6160013 | 0.92 | ALDH1A1 (0.44) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL6160532 | 0.89 | HDAC1 (0.39) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL6160530 | 0.89 | HDAC1 (0.39) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL6165686 | 0.87 | HDAC1 (0.38) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL6162653 | 0.87 | MMP12 (0.43) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL6165693 | 0.87 | HDAC1 (0.38) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL6162656 | 0.87 | MMP12 (0.43) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL6165484 | 0.85 | NPC1 (0.39) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | claimed |
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |