Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939769 | 0.82 | LTA4H (0.42) | ALDH1A1GAASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL8939773 | 0.74 | KDM4E (0.41) | ALDH1A1GAAKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL8939758 | 0.74 | APP (0.41) | ALDH1A1GAA | |
| SCHEMBL6575991 | 0.72 | MAPK1 (0.48) | ALDH1A1SMN1; SMN2HSD17B10KDM4EPOLB | |
| SCHEMBL8939787 | 0.72 | LTA4H (0.42) | ALDH1A1KMT2ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL8190525 | 0.72 | MEN1 (0.47) | ALDH1A1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL6160386 | 0.72 | ABCB1 (0.44) | SMN1; SMN2POLB | |
| SCHEMBL27588491 | 0.70 | CNR1 (0.42) | ALDH1A1HSD17B10KDM4EHPGDRECQL | |
| SCHEMBL7746427 | 0.70 | HTR2A (0.42) | HPGD | |
| SCHEMBL7429582 | 0.70 | BCHE (0.40) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129070-A4 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-1129070-A1 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027811-A1 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |