Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669791 | 0.96 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GAAMAPK1KDM4E | |
| SCHEMBL5697246 | 0.95 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2GAAMAPK1KDM4E | |
| SCHEMBL5792711 | 0.84 | KDM4E (0.50) | ALDH1A1SMN1; SMN2GAAKDM4ECHRNA7 | |
| SCHEMBL22290361 | 0.84 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2HPGDNPSR1POLB | |
| SCHEMBL11564055 | 0.82 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2GAAMAPK1KDM4E | |
| SCHEMBL30153751 | 0.81 | CHRNB1 (0.47) | ALDH1A1SMN1; SMN2GAAMAPK1KDM4E | |
| SCHEMBL27680432 | 0.81 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2GAAMAPK1KDM4E | |
| SCHEMBL830088 | 0.80 | KMT2A (0.52) | ALDH1A1SMN1; SMN2GAAMAPK1KDM4E | |
| SCHEMBL15085744 | 0.80 | GAA (0.58) | ALDH1A1SMN1; SMN2GAAMAPK1KDM4E | |
| SCHEMBL28617751 | 0.79 | SMN1; SMN2 (0.72) | ALDH1A1SMN1; SMN2GAAMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110709391-A | Modulators of indoleamine2, 3-dioxygenase | 葛兰素史克知识产权开发有限公司 | 2020-01-17 | — | — | CN | disclosed |
| EP-1499589-A1 | DERIVATIVES OF N-PHENYL(PIPERIDIN-2-YL)METHYL BENZAMIDE, THE PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2005-01-26 | — | — | EP | disclosed |
| WO-2004013100-A2 | N-[PHENYL(PIPERIDIN-2-YL)METHYL]BENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN THERAPY | SANOFI-AVENTIS (FR) | 2004-02-12 | — | — | WO | disclosed |
| WO-2003089411-A1 | DERIVATIVES OF N-[PHENYL(PIPERIDIN-2-YL)METHYL]BENZAMIDE, THE PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2003-10-30 | — | — | WO | disclosed |