Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 15/20 | 1.00 |
| ▸ | EGFR | P00533 | 1/20 | 0.69 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.66 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14587604 | 1.00 | PYGL (1.00) | PYGLEGFRCYP51A1CTNNB1 | |
| SCHEMBL29360910 | 0.94 | PYGL (0.88) | PYGLEGFRCYP51A1CTNNB1 | |
| Phenylalanine Methyl Ester SCHEMBL9051782 | 0.93 | PYGL (0.87) | PYGLEGFRCYP51A1CTNNB1 | |
| SCHEMBL6162920 | 0.92 | PYGL (0.85) | PYGLEGFRCYP51A1 | |
| SCHEMBL6162905 | 0.91 | PYGL (0.83) | PYGLEGFRCYP51A1 | |
| SCHEMBL6162901 | 0.91 | PYGL (0.83) | PYGLEGFRCYP51A1 | |
| SCHEMBL29358053 | 0.90 | PYGL (0.81) | PYGLCTNNB1 | |
| SCHEMBL6339472 | 0.90 | PYGL (0.81) | PYGLEGFRCTNNB1 | |
| SCHEMBL6165218 | 0.90 | PYGL (0.81) | PYGLEGFRCYP51A1CTNNB1 | |
| SCHEMBL6165213 | 0.90 | PYGL (0.81) | PYGLEGFRCYP51A1CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0832065-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |