Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2466886 | 0.92 | CYP2A6 (0.54) | DPP4DPP8DPP9CYP2A6ALPI | |
| SCHEMBL514508 | 0.92 | CYP2A6 (0.54) | DPP4DPP8DPP9CYP2A6ALPI | |
| SCHEMBL1421072 | 0.92 | CYP2A6 (0.54) | DPP4DPP8DPP9CYP2A6ALPI | |
| SCHEMBL29373380 | 0.92 | CYP2A6 (0.54) | DPP4DPP8DPP9CYP2A6ALPI | |
| SCHEMBL514509 | 0.92 | CYP2A6 (0.54) | DPP4DPP8DPP9CYP2A6ALPI | |
| Hydrochloric Acid SCHEMBL4903646 | 0.90 | CYP2A6 (0.53) | DPP4DPP8DPP9CYP2A6ALPI | |
| Hydrochloric Acid SCHEMBL31036845 | 0.90 | CYP2A6 (0.53) | DPP4DPP8DPP9CYP2A6ALPI | |
| Hydrochloric Acid SCHEMBL4903643 | 0.90 | CYP2A6 (0.53) | DPP4DPP8DPP9CYP2A6ALPI | |
| SCHEMBL6161396 | 0.81 | DPP4 (0.46) | DPP4DPP8DPP9CYP2A6OPRD1 | |
| SCHEMBL28905932 | 0.80 | CYP2A6 (0.54) | DPP4DPP8DPP9CYP2A6OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1996035713-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER, INC. (US) | 1996-11-14 | — | — | WO | disclosed |