Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.62 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9521523 | 0.87 | SIGMAR1 (1.00) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL7402939 | 0.84 | SIGMAR1 (0.75) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL866873 | 0.83 | SIGMAR1 (1.00) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL7405795 | 0.83 | SIGMAR1 (0.72) | SIGMAR1HRH3CHRM4 | |
| SCHEMBL7469402 | 0.82 | HRH3 (0.60) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9373391 | 0.81 | SIGMAR1 (1.00) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL8468794 | 0.81 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL7319920 | 0.80 | SIGMAR1 (0.69) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL7402940 | 0.80 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL7372250 | 0.80 | SIGMAR1 (0.81) | SIGMAR1MEN1TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| US-6048876-A | ANTICONVULSANTS; ANTIEPILEPIC AGENT | SUNTORY LIMITED (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |