SCHEMBL6161643

SCHEMBL6161643

C1=C(c2ccccc2)CCN(CCCCn2cc3ccccc3n2)C1

nearest known ligand 0.55

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.55
PARP1 P09874 6/20 0.53
DRD4 P21917 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5846473 0.91 PARP1 (0.55) SIGMAR1PARP1
SCHEMBL6159703 0.76 SIGMAR1 (0.62) SIGMAR1PARP1DRD4
SCHEMBL5847491 0.76 SIGMAR1 (0.58) SIGMAR1PARP1DRD4
SCHEMBL6161789 0.75 SIGMAR1 (0.60) SIGMAR1PARP1DRD4
Hydrochloric Acid SCHEMBL5846250 0.75 SIGMAR1 (0.60) SIGMAR1PARP1DRD4
SCHEMBL5846061 0.75 SIGMAR1 (0.60) SIGMAR1PARP1DRD4
SCHEMBL7297566 0.74 SIGMAR1 (0.63) SIGMAR1PARP1DRD4
SCHEMBL5544346 0.74 SIGMAR1 (0.63) SIGMAR1PARP1
SCHEMBL256663 0.74 SIGMAR1 (0.63) SIGMAR1PARP1
SCHEMBL9466847 0.74 SIGMAR1 (0.63) SIGMAR1PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
US-6232329-B1 POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-15 US claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed