SCHEMBL5847491

SCHEMBL5847491

Clc1cnn(CCCCN2CC=C(c3ccccc3)CC2)c1

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.58
HTR1A P08908 3/20 0.49
DRD2 P14416 1/20 0.48
DRD4 P21917 1/20 0.48
DRD3 P35462 1/20 0.48
PARP1 P09874 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5846299 0.98 SIGMAR1 (0.55) SIGMAR1HTR1ADRD2DRD4DRD3
SCHEMBL5846267 0.91 SIGMAR1 (0.60) SIGMAR1HTR1ADRD2PARP1
Hydrochloric Acid SCHEMBL6165778 0.90 SIGMAR1 (0.59) SIGMAR1HTR1ADRD2PARP1
SCHEMBL5847759 0.89 SIGMAR1 (0.56) SIGMAR1HTR1ADRD2PARP1
SCHEMBL5846958 0.89 SIGMAR1 (0.63) SIGMAR1HTR1ADRD2PARP1
SCHEMBL6162324 0.88 SIGMAR1 (0.57) SIGMAR1HTR1ADRD2PARP1
SCHEMBL5848161 0.88 SIGMAR1 (0.60) SIGMAR1HTR1ADRD4PARP1
Hydrochloric Acid SCHEMBL5847621 0.88 SIGMAR1 (0.61) SIGMAR1HTR1APARP1
Hydrochloric Acid SCHEMBL7115716 0.87 SIGMAR1 (0.56) SIGMAR1HTR1ADRD2PARP1
SCHEMBL6161845 0.85 HTR7 (0.54) SIGMAR1HTR1APARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39113-E1 Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain LABORATORIES DEL DR. ESTEVE, S.A. (ES) 2006-05-30 US claimed
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
US-6384055-B1 ANALGESICS LABORATORIOS DEL DR. ESTEVES, S.A. (ES) 2002-05-07 US claimed
US-6232329-B1 POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-15 US claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed