Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | DRD5 | P21918 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159051 | 0.88 | SLC18A3 (0.61) | SLC18A3 | |
| SCHEMBL11790517 | 0.83 | DRD2 (0.63) | SLC18A3DRD2DRD3HTR2AHTR1A | |
| SCHEMBL6162714 | 0.82 | HTR1A (0.70) | DRD2DRD3HTR2AHTR1ASIGMAR1 | |
| SCHEMBL9092128 | 0.82 | HTR1A (0.56) | SLC18A3DRD2HTR1ASIGMAR1SLC6A4 | |
| SCHEMBL6161874 | 0.82 | HRH3 (0.69) | HRH3DRD2DRD3HTR2AHTR1A | |
| SCHEMBL6159068 | 0.80 | DRD2 (0.81) | SLC18A3HRH3DRD2DRD3HTR2A | |
| SCHEMBL6159055 | 0.79 | HRH3 (0.65) | HRH3DRD2DRD3HTR2AHTR1A | |
| SCHEMBL9092197 | 0.77 | DRD2 (0.58) | DRD2DRD3HTR2AHTR1ADRD1 | |
| SCHEMBL9076786 | 0.77 | HTR2A (0.62) | DRD2DRD3HTR2AHTR1ASIGMAR1 | |
| SCHEMBL10761329 | 0.76 | BCHE (0.64) | SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |