Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.59 |
| ▸ | DRD2 | P14416 | 4/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161877 | 0.82 | SLC18A3 (0.55) | HTR1ASIGMAR1DRD2DRD3HTR2A | |
| SCHEMBL6167407 | 0.82 | HTR1A (0.67) | HTR1ASIGMAR1DRD2DRD3HTR2A | |
| SCHEMBL6162706 | 0.81 | HTR1A (0.79) | HTR1ASIGMAR1DRD2DRD3HTR2A | |
| SCHEMBL2883152 | 0.77 | HTR1A (0.79) | HTR1AHTR2ASLC6A4SLC6A3SLC6A2 | |
| SCHEMBL10635609 | 0.76 | SLC6A4 (0.88) | SIGMAR1CYP1A2CYP2C9SLC6A4SLC6A3 | |
| Anisopirol SCHEMBL2111067 | 0.76 | HTR1A (0.74) | HTR1ASIGMAR1DRD2DRD3 | |
| SCHEMBL10485888 | 0.75 | HTR1A (0.64) | HTR1ASIGMAR1DRD2DRD3HTR2A | |
| Hydrochloric Acid SCHEMBL11077810 | 0.75 | SLC6A4 (0.86) | SIGMAR1CYP1A2CYP2C9SLC6A4SLC6A3 | |
| SCHEMBL1460235 | 0.75 | KMT2A (0.80) | HTR1AKDM4ESLC6A4SLC6A3SLC6A2 | |
| SCHEMBL13532634 | 0.74 | DRD2 (1.00) | HTR1ASIGMAR1DRD2DRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |