Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9562382 | 0.85 | NAMPT (0.46) | NAMPTKDM4EALDH1A1 | |
| SCHEMBL17553578 | 0.84 | CHRNB2 (0.49) | SMN1; SMN2NAMPTMAPTKDM4EALDH1A1 | |
| SCHEMBL27501271 | 0.82 | GBA1 (0.49) | GBA1 | |
| SCHEMBL5839598 | 0.81 | GBA1 (0.47) | GBA1 | |
| SCHEMBL30136036 | 0.81 | CYP17A1 (0.49) | GBA1NAMPTMAPT | |
| SCHEMBL16787788 | 0.80 | GBA1 (0.56) | GBA1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8648753 | 0.80 | GBA1 (0.56) | GBA1POLBMAPTNPSR1ALDH1A1 | |
| SCHEMBL30135893 | 0.78 | RAB9A (0.53) | SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL16653885 | 0.77 | SLC6A2 (0.52) | SMN1; SMN2NAMPTMAPTKDM4EALDH1A1 | |
| SCHEMBL10127506 | 0.76 | NAMPT (0.59) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089735-B1 | 4-BENZYL PIPERIDINE ALKYLSULFOXIDE HETEROCYCLES AND THEIR USE AS SUBTYPE-SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-0763535-B1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GMBH (DE) | 2002-11-27 | — | — | EP | disclosed |
| US-6284774-B1 | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | WARNER-LAMBERT COMPANY | 2001-09-04 | — | — | US | disclosed |
| CN-1304307-A | 4-benzyl piperidine alkylsulfoxide heterocycles and their use as subtype-selective NMDA receptor antagonists | WARNER LAMBER CO (US) | 2001-07-18 | — | — | CN | disclosed |
| US-5714502-A | Piperidinylmethyloxazolidinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-02-03 | — | — | US | disclosed |
| EP-0763535-A1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |