SCHEMBL6162285

SCHEMBL6162285

CC(C)(N)C(=O)NC(COCc1ccccc1)C(=O)N1CCC(CCc2noc3cc(NC(=O)c4ccccc4)ccc23)CC1

nearest known ligand 0.62

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ACHE P22303 10/20 0.62
BCHE P06276 2/20 0.53
CCKBR P32239 3/20 0.46
GHSR Q92847 4/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6161716 1.00 ACHE (0.62) ACHEBCHECCKBRGHSR
SCHEMBL9411245 0.79 ACHE (0.76) ACHEBCHE
SCHEMBL6161605 0.79 ACHE (0.71) ACHEBCHE
SCHEMBL9411572 0.79 ACHE (0.77) ACHEBCHE
SCHEMBL7090686 0.77 ACHE (1.00) ACHEBCHE
SCHEMBL6163682 0.77 GHSR (0.53) CCKBRGHSR
SCHEMBL6163691 0.77 GHSR (0.53) CCKBRGHSR
SCHEMBL6164572 0.76 GHSR (0.52) CCKBRGHSR
SCHEMBL6164577 0.76 GHSR (0.52) CCKBRGHSR
Hydrochloric Acid SCHEMBL6164015 0.75 GHSR (0.51) CCKBRGHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828754-B1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER (US) 2005-02-02 EP claimed
EP-0828754-B1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER (US) 2005-02-02 EP disclosed
CN-1143647-A Dipeptides which promote release of growth hormone PFIZER (US) 1997-02-26 CN disclosed