SCHEMBL6163413

SCHEMBL6163413

COC(=O)c1oc(C(C)(C)C)cc1NC(=O)Nc1ccc(NCc2ccncc2)c2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 8/20 0.53
RAF1 P04049 3/20 0.53
ALDH1A1 P00352 2/20 0.47
NPC1 O15118 1/20 0.40
POLB P06746 1/20 0.40
RAB9A P51151 1/20 0.40
TNF P01375 1/20 0.40
HCK P08631 1/20 0.40
MAPK12 P53778 1/20 0.40
MEN1 O00255 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
GSK3A P49840 1/20 0.39
CCR8 P51685 1/20 0.39
TRPV1 Q8NER1 1/20 0.38
CDC7 O00311 1/20 0.38
ROCK2 O75116 1/20 0.38
MAP4K4 O95819 1/20 0.38
GSK3B P49841 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6163825 0.87 MAPK14 (0.51) MAPK14RAF1ALDH1A1NPC1POLB
SCHEMBL7665705 0.86 MAPK14 (0.50) MAPK14RAF1ALDH1A1TNFHCK
SCHEMBL6162310 0.85 MAPK14 (0.58) MAPK14RAF1TNFHCKMAPK12
SCHEMBL6163672 0.84 MAPK14 (0.53) MAPK14RAF1TNFHCKMAPK12
SCHEMBL6163420 0.81 MAPK14 (0.51) MAPK14RAF1ALDH1A1NPC1POLB
SCHEMBL6163294 0.75 MAPK14 (0.61) MAPK14RAF1TNFHCKMAPK12
SCHEMBL6165244 0.74 MAPK14 (0.50) MAPK14RAF1TNFHCKMAPK12
SCHEMBL6165058 0.74 MAPK14 (0.55) MAPK14RAF1ALDH1A1MAPK12CCR8
SCHEMBL6160851 0.73 MAPK14 (0.50) MAPK14RAF1TNFHCKMAPK12
SCHEMBL6161474 0.72 MAPK14 (0.63) MAPK14RAF1ALDH1A1TNFHCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1163236-B1 AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS BOEHRINGER INGELHEIM PHARMA (US) 2005-11-09 EP disclosed
US-6476023-B1 Aromatic heterocyclic compounds as anti-inflammatory agents BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. 2002-11-05 US disclosed
EP-1163236-A1 AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2001-12-19 EP disclosed
US-6297381-B1 INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2001-10-02 US disclosed
WO-2000055152-A1 AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-09-21 WO disclosed