Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 13/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073041 | 0.75 | ALDH1A1 (0.62) | SMN1; SMN2ALDH1A1LMNACYP2D6CYP2C19 | |
| SCHEMBL31689136 | 0.74 | MAPK8 (0.55) | MAPK8NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8623265 | 0.74 | LMNA (0.64) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13147514 | 0.73 | NPC1 (0.58) | MAPK8NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14861310 | 0.73 | LMNA (0.50) | ALDH1A1LMNACYP2D6CYP2C19KMT2A | |
| SCHEMBL3345536 | 0.71 | HTT (0.41) | NPC1RAB9AALDH1A1LMNACYP2D6 | |
| SCHEMBL631087 | 0.68 | MAPK8 (0.49) | MAPK8NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL18343734 | 0.68 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4071827 | 0.68 | ALDH1A1 (0.60) | SMN1; SMN2ALDH1A1MAPTLMNACYP2D6 | |
| SCHEMBL6167127 | 0.68 | TAAR1 (0.48) | SMN1; SMN2ALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |