Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 7/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253095 | 0.83 | KDM4E (0.56) | MAP2ALDH1A1HPGDKDM4E | |
| SCHEMBL27442503 | 0.79 | MAP2 (0.59) | MAP2ALDH1A1KDM4E | |
| SCHEMBL8795558 | 0.77 | ALOX15 (0.68) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL16610191 | 0.75 | ALOX15 (0.81) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL1504534 | 0.75 | ALDH1A1 (0.68) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL1504139 | 0.72 | ALOX15 (0.61) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL17373720 | 0.72 | ALDH1A1 (0.69) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL13758172 | 0.71 | ALDH1A1 (0.76) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL8689527 | 0.70 | ALDH1A1 (0.69) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL4077176 | 0.70 | ALDH1A1 (0.69) | ALOX15ALDH1A1CYP1A2HPGDXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0832065-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |