Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MAP2 | P11137 | 6/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.55 |
| ▸ | TUBB | P07437 | 5/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.55 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.55 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.55 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.55 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.55 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.55 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262790 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1HPGDMAP2TUBB4A | |
| SCHEMBL25751659 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1HPGDMAP2TUBB4A | |
| SCHEMBL6162693 | 0.83 | MAP2 (0.50) | KDM4EALDH1A1HPGDMAP2 | |
| SCHEMBL27442503 | 0.82 | MAP2 (0.59) | KDM4EALDH1A1MAP2 | |
| SCHEMBL21465510 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1HPGDMAP2TUBB4A | |
| SCHEMBL21465557 | 0.80 | TUBB4A (0.65) | KDM4EALDH1A1HPGDMAP2TUBB4A | |
| SCHEMBL6308065 | 0.80 | KDM4E (0.58) | KDM4EALDH1A1HPGDMAP2TUBB4A | |
| SCHEMBL3246965 | 0.80 | NR4A2 (0.60) | KDM4EALDH1A1HPGDMAP2TUBB4A | |
| SCHEMBL5234954 | 0.78 | NR4A2 (0.63) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL5402454 | 0.78 | ALOX15 (0.60) | KDM4EALDH1A1HPGDMAP2TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651639-B1 | BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS | ARPIDA AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| US-7524854-B2 | Benzofuran derivatives and their use in the treatment of microbial infections | ARPIDA AG (CH) | 2009-04-28 | — | — | US | disclosed |
| US-20060154943-A1 | Benzofuran derivatives and their use in the treatment of microbial infections | ARPIDA AG (CH) | 2006-07-13 | — | — | US | disclosed |
| EP-1651639-A1 | BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS | Arpida AG, (CH) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005005418-A1 | BENZOFURAN DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS | ARPIDA AG (CH) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154943-A1 | Benzofuran derivatives and their use in the treatment of microbial infections | DCXR, NLRP3, NISCH | KDM4E 1957/4885ALDH1A1 891/4885HPGD 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.