Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 11/20 | 0.71 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.61 |
| ▸ | ALB | P02768 | 1/20 | 0.55 |
| ▸ | IL2 | P60568 | 1/20 | 0.55 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162694 | 1.00 | PYGL (0.71) | PYGLCYP51A1ALBIL2CTNNB1 | |
| SCHEMBL6160275 | 0.85 | PYGL (0.78) | PYGLCYP51A1ALBIL2 | |
| SCHEMBL6165239 | 0.85 | PYGL (0.78) | PYGLCYP51A1ALBIL2 | |
| SCHEMBL2735826 | 0.78 | EGFR (0.76) | PYGLCYP51A1ALBIL2TDP1 | |
| SCHEMBL14587604 | 0.78 | PYGL (1.00) | PYGLCYP51A1CTNNB1 | |
| SCHEMBL6161267 | 0.78 | PYGL (1.00) | PYGLCYP51A1CTNNB1 | |
| SCHEMBL2107315 | 0.77 | PYGL (0.50) | PYGLCYP51A1POLBMAPTTDP1 | |
| SCHEMBL2107313 | 0.77 | PYGL (0.50) | PYGLCYP51A1POLBMAPTTDP1 | |
| SCHEMBL13943844 | 0.77 | PYGL (0.45) | PYGLCYP51A1ALBIL2POLB | |
| SCHEMBL6345409 | 0.76 | PYGL (0.65) | PYGLCYP51A1ALBIL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0832065-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |