Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | UGT1A1 | P22309 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | TPH1 | P17752 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6162810 | 0.99 | DPP4 (0.55) | DPP4UGT1A1F2F10PRSS1 | |
| SCHEMBL30722996 | 0.83 | TPH1 (0.61) | DPP4TPH1HCAR2 | |
| SCHEMBL7610102 | 0.83 | TPH1 (0.61) | DPP4TPH1HCAR2 | |
| SCHEMBL7610098 | 0.83 | TPH1 (0.61) | DPP4TPH1HCAR2 | |
| SCHEMBL6163441 | 0.83 | TPH1 (0.45) | TPH1CA12CA1CA2CA5A | |
| SCHEMBL539645 | 0.83 | CYP2D6 (0.44) | DPP4UGT1A1TPH1CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL539644 | 0.82 | ALDH1A1 (0.46) | DPP4UGT1A1TPH1CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL539646 | 0.82 | ALDH1A1 (0.46) | DPP4UGT1A1TPH1CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL6163436 | 0.82 | TPH1 (0.44) | TPH1CA12CA1CA2CA5A | |
| Hydrochloric Acid SCHEMBL31407613 | 0.82 | DPP4 (0.51) | DPP4UGT1A1F2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | disclosed |
| CN-1071325-C | Thiol derivatives having metallopeptidase inhibitory activity | ZAMBON SPA (IT) | 2001-09-19 | — | — | CN | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| CN-1206411-A | Thiol derivatives with metallopeptidase inhibitory activity | ZAMBON SPA (IT) | 1999-01-27 | — | — | CN | disclosed |
| US-5760241-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS; CARDIOVASCULAR DISORDERS | ZAMBON GROUP S.P.A. (IT) | 1998-06-02 | — | — | US | disclosed |