Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 3/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161724 | 0.91 | MAPK1 (0.50) | MAPK1CAPN1CTSBKMT2ACACNA1B | |
| SCHEMBL6161717 | 0.91 | MAPK1 (0.50) | MAPK1CAPN1CTSBKMT2ACACNA1B | |
| SCHEMBL6163821 | 0.91 | MAPK1 (0.48) | MAPK1CAPN1CTSBKMT2ACACNA1B | |
| SCHEMBL6166209 | 0.87 | MAPK1 (0.49) | MAPK1CAPN1CTSBKMT2ACACNA1B | |
| SCHEMBL6166213 | 0.87 | MAPK1 (0.49) | MAPK1CAPN1CTSBKMT2ACACNA1B | |
| SCHEMBL6168374 | 0.85 | MAPK1 (0.51) | MAPK1CAPN1CTSBKMT2AYAP1 | |
| SCHEMBL6168383 | 0.85 | MAPK1 (0.51) | MAPK1CAPN1CTSBKMT2AYAP1 | |
| SCHEMBL6161443 | 0.83 | P2RX7 (0.47) | MAPK1KMT2APLAUPLATALDH1A1 | |
| SCHEMBL8411771 | 0.81 | TP53 (0.38) | KMT2AALDH1A1LMNASTS | |
| SCHEMBL6162914 | 0.80 | MAPK1 (0.62) | MAPK1CAPN1CTSBKMT2ACACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0828754-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038471-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1996-12-05 | — | — | WO | disclosed |