Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.73 |
| ▸ | CTSK | P43235 | 10/20 | 0.73 |
| ▸ | CTSB | P07858 | 4/20 | 0.73 |
| ▸ | CTSL | P07711 | 2/20 | 0.73 |
| ▸ | AKT1 | P31749 | 1/20 | 0.63 |
| ▸ | ACE | P12821 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 2/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | REN | P00797 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163823 | 1.00 | CTSS (0.73) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL30279703 | 1.00 | CTSS (0.73) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL6163323 | 1.00 | CTSS (0.73) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL20669382 | 0.97 | CTSS (0.70) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL3698861 | 0.93 | CTSS (0.74) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL3698863 | 0.93 | CTSS (0.74) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL6353725 | 0.91 | CTSS (0.65) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL7029483 | 0.91 | CTSS (0.65) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL22928874 | 0.91 | REN (0.71) | CTSSCTSKCTSBCTSLREN | |
| SCHEMBL7283537 | 0.89 | MMP9 (0.69) | CTSSCTSKCTSBCTSLHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3521301-A1 | POLYAMIDE COMPOUND AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2019-08-07 | — | — | EP | disclosed |
| WO-2018059331-A1 | POLYAMIDE COMPOUND AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2018-04-05 | — | — | WO | disclosed |
| EP-3044204-B1 | A PHOTOLABILE LINKER FOR THE SOLID-PHASE SYNTHESIS OF HYDRAZIDES AND PYRANOPYRAZOLES | UNIV DANMARKS TEKNISKE (DK) | 2017-11-08 | — | — | EP | disclosed |
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0832065-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |