Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | REN | P00797 | 3/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.47 |
| ▸ | FAP | Q12884 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9494667 | 1.00 | OPRD1 (0.55) | OPRD1F2PRSS1HDAC8POLB | |
| SCHEMBL13540967 | 0.88 | OPRD1 (0.60) | OPRD1F2PRSS1HDAC8POLB | |
| SCHEMBL7352495 | 0.87 | REN (0.51) | REN | |
| SCHEMBL7317592 | 0.87 | REN (0.51) | REN | |
| SCHEMBL7352491 | 0.87 | REN (0.51) | REN | |
| SCHEMBL7361787 | 0.82 | REN (0.59) | REN | |
| SCHEMBL9442934 | 0.82 | REN (0.59) | REN | |
| SCHEMBL7360693 | 0.81 | HPGD (0.66) | OPRD1HDAC8POLBOPRK1DPP4 | |
| SCHEMBL7975223 | 0.81 | HPGD (0.47) | F2PRSS1REN | |
| SCHEMBL7347289 | 0.81 | KDM4E (0.49) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-5244910-A | Treating hypertension, congestive heart failure | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |