SCHEMBL6163822

SCHEMBL6163822

Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(C(=O)O)C3)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA1 Q09470 6/20 0.72
KCNAB1 Q14722 6/20 0.72
ALDH1A1 P00352 2/20 0.62
LMNA P02545 2/20 0.62
THRB P10828 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
HPGD P15428 1/20 0.53
HSD17B10 Q99714 1/20 0.53
DPP4 P27487 1/20 0.52
CYP1A2 P05177 2/20 0.51
CYP3A4 P08684 2/20 0.51
CYP2C9 P11712 2/20 0.51
CYP2C19 P33261 2/20 0.51
DRD2 P14416 2/20 0.51
HTR2A P28223 2/20 0.51
HTR2C P28335 2/20 0.51
DRD3 P35462 2/20 0.51
HTR6 P50406 2/20 0.51
CYP2D6 P10635 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16634913 0.84 KCNA1 (0.49) KCNA1KCNAB1SMN1; SMN2TP53TMPRSS2
SCHEMBL1946003 0.84 KCNA1 (1.00) KCNA1KCNAB1ALDH1A1LMNATHRB
SCHEMBL1944493 0.82 KCNA1 (0.92) KCNA1KCNAB1ALDH1A1LMNATHRB
SCHEMBL1946008 0.80 KCNA1 (1.00) KCNA1KCNAB1ALDH1A1LMNATHRB
SCHEMBL5242130 0.79 MAPT (0.51) KCNA1KCNAB1ALDH1A1LMNAHPGD
SCHEMBL1948779 0.78 KCNA1 (0.65) KCNA1KCNAB1ALDH1A1LMNATHRB
SCHEMBL1945514 0.78 ALDH1A1 (0.71) KCNA1KCNAB1ALDH1A1LMNATHRB
SCHEMBL1947206 0.78 KCNA1 (1.00) KCNA1KCNAB1ALDH1A1LMNASMN1; SMN2
SCHEMBL10564280 0.78 KCNA1 (0.59) KCNA1KCNAB1ALDH1A1LMNATHRB
SCHEMBL17969238 0.77 TMPRSS2 (0.44) KCNA1KCNAB1SMN1; SMN2TP53TMPRSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
EP-0828754-B1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER (US) 2005-02-02 EP disclosed
US-5936089-A PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER PFIZER INC (US) 1999-08-10 US disclosed