Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | KCNA1 | Q09470 | 3/20 | 0.67 |
| ▸ | KCNAB1 | Q14722 | 3/20 | 0.67 |
| ▸ | DPP4 | P27487 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 6/20 | 0.58 |
| ▸ | HTR2A | P28223 | 6/20 | 0.58 |
| ▸ | HTR2C | P28335 | 6/20 | 0.58 |
| ▸ | DRD3 | P35462 | 6/20 | 0.58 |
| ▸ | HTR6 | P50406 | 6/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12540053 | 0.83 | KCNA1 (0.77) | LMNAKCNA1KCNAB1TP53POLB | |
| SCHEMBL1946003 | 0.81 | KCNA1 (1.00) | ALDH1A1LMNASMN1; SMN2THRBL3MBTL1 | |
| SCHEMBL1946627 | 0.80 | LMNA (0.77) | ALDH1A1LMNASMN1; SMN2THRBL3MBTL1 | |
| SCHEMBL1949180 | 0.79 | PKM (0.54) | ALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL6163822 | 0.78 | KCNA1 (0.72) | ALDH1A1LMNASMN1; SMN2THRBL3MBTL1 | |
| SCHEMBL1016818 | 0.77 | PKM (0.62) | ALDH1A1LMNAL3MBTL1POLB | |
| SCHEMBL1944493 | 0.77 | KCNA1 (0.92) | ALDH1A1LMNASMN1; SMN2THRBL3MBTL1 | |
| SCHEMBL6623996 | 0.76 | ALDH1A1 (0.71) | ALDH1A1LMNASMN1; SMN2THRBL3MBTL1 | |
| SCHEMBL1946363 | 0.75 | AKR1C3 (0.55) | ALDH1A1LMNAL3MBTL1POLB | |
| SCHEMBL6149579 | 0.75 | LMNA (0.69) | ALDH1A1LMNASMN1; SMN2THRBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130383-A1 | Use of Ion Channel Modulators in the Prophylaxis and Treatment of Inflammatory and Immunological Diseases | LECTUS THERAPEUTICS LIMITED (GB) | 2011-06-02 | — | — | US | disclosed |
| US-20090318423-A1 | Ion Channel Modulators & Uses Thereof | LECTUS THERAPEUTICS LIMITED (GB) | 2009-12-24 | — | — | US | disclosed |
| EP-2069309-A1 | ION CHANNEL MODULATORS&USES THEREOF | Lectus Therapeutics Limited (GB) | 2009-06-17 | — | — | EP | disclosed |
| EP-2066317-A2 | USE OF ION CHANNEL MODULATORS IN THE PROPHYLAXIS AND TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISEASES | Lectus Therapeutics Limited (GB) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008038053-A1 | ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |
| WO-2008038051-A2 | USE OF ION CHANNEL MODULATORS IN THE PROPHYLAXIS AND TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISEASES | LECTUS THERAPEUTICS LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318423-A1 | Ion Channel Modulators & Uses Thereof | KCNH3, KCNN3, KCNH2 | ALDH1A1 1965/4885LMNA 3429/4885SMN1; SMN2 3625/4885 |
| US-20110130383-A1 | Use of Ion Channel Modulators in the Prophylaxis and Treatment of Inflammatory and Immunological Diseases | HCAR2, HCAR1, SCN7A | ALDH1A1 2831/4885LMNA 3982/4885SMN1; SMN2 4159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.