Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164597 | 0.94 | NPC1 (0.36) | MAPTALDH1A1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL6166806 | 0.91 | APP (0.39) | MAPTALDH1A1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL6166598 | 0.89 | PDE10A (0.47) | MAPTALDH1A1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL6166432 | 0.88 | TP53 (0.35) | MAPTALDH1A1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL6162645 | 0.88 | LMNA (0.41) | MAPTALDH1A1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL6166932 | 0.88 | RAB9A (0.36) | MAPTALDH1A1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL6164872 | 0.88 | ALDH1A1 (0.35) | MAPTALDH1A1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL6167088 | 0.88 | TP53 (0.34) | MAPTALDH1A1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL6165463 | 0.88 | RAB9A (0.41) | MAPTALDH1A1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL6183323 | 0.86 | ALDH1A1 (0.37) | MAPTALDH1A1NPSR1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |