SCHEMBL6163963

SCHEMBL6163963

O=C(O)CC(Sc1c(F)c(F)nc(F)c1F)C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
POLB P06746 3/20 0.42
KDM4E B2RXH2 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
APOBEC3G Q9HC16 1/20 0.42
KMT2A Q03164 4/20 0.33
MEN1 O00255 3/20 0.33
ATM Q13315 1/20 0.33
CPB1 P15086 1/20 0.33
NPSR1 Q6W5P4 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6166784 0.83
SCHEMBL6161989 0.74 KDM4E (0.46) ALDH1A1KDM4ENPSR1SMN1; SMN2LMNA
SCHEMBL6163264 0.67 ALDH1A1 (0.35) ALDH1A1KDM4ETDP1KMT2AMEN1
SCHEMBL6161347 0.66 CA12 (0.56) ALDH1A1POLBTDP1KMT2ANPSR1
SCHEMBL9834413 0.66 ALDH1A1 (0.61) ALDH1A1POLBKDM4ETDP1APOBEC3G
SCHEMBL6164956 0.66 KIF11 (0.37) ALDH1A1
SCHEMBL12445751 0.65 CYP1A2 (0.37) ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2
SCHEMBL10824817 0.63 ALDH1A1 (0.51) ALDH1A1POLBKDM4ETDP1APOBEC3G
SCHEMBL630577 0.63 TDP1 (0.48) ALDH1A1POLBKDM4ETDP1APOBEC3G
SCHEMBL10729283 0.63 TDP1 (0.48) ALDH1A1POLBKDM4ETDP1APOBEC3G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934310-B1 THIO ACID DERIVED MONOCYCLIC N-HETEROCYCLICS AS ANTICOAGULANTS SCHERING AG (DE) 2005-02-09 EP disclosed
US-6221886-B1 Thio acid derived monocyclic N-heterocyclics as anticoagulants BERLEX LABORATORIES, INC. 2001-04-24 US disclosed
US-6166014-A Thio acid derived monocyclic N-heterocyclics as anticoagulants BERLEX LABORATORIES, INC. (US) 2000-12-26 US disclosed
US-6162807-A Thio acid derived monocyclic N-heterocyclics as anticoagulants BERLEX LABORATORIES, INC. (US) 2000-12-19 US disclosed
US-6150382-A ENZYME INHIBITORS OF BLOOD COAGULATION FACTOR XA, A SERINE PROTEASE CLASS OF ENZYMES; E.G., 4-HYDROXY-3-((4-(2-CARBOXY-METHYL)THIO-6-(3-(1-METHYL)-6-(3-(1 -METHYL)IMIDAZOLIN-2-YL)-PHENOXY-3,5-DIFLUOROPYRIDINE AND DERIVATIVES BERLEX LABORATORIES, INC. (US) 2000-11-21 US disclosed
US-6034084-A CARDIOVASCULAR DISORDERS BERLEX LABORATORIES, INC. (US) 2000-03-07 US disclosed
US-6004985-A BLOOD-COAGULATION FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. (US) 1999-12-21 US disclosed
EP-0934310-A1 THIO ACID DERIVED MONOCYCLIC $i(N)-HETEROCYCLICS AS ANTICOAGULANTS SCHERING AKTIENGESELLSCHAFT (DE) 1999-08-11 EP disclosed
WO-1998015547-A1 THIO ACID DERIVED MONOCYCLIC N-HETEROCYCLICS AS ANTICOAGULANTS SCHERING AKTIENGESELLSCHAFT (DE) 1998-04-16 WO disclosed