Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 20/20 | 0.67 |
| ▸ | CDK2 | P24941 | 20/20 | 0.67 |
| ▸ | CCNO | P22674 | 2/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.67 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.67 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164644 | 0.81 | CCNA2 (0.76) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6164739 | 0.81 | CCNA2 (1.00) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6164565 | 0.81 | CCNA2 (1.00) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6165208 | 0.79 | CCNA2 (1.00) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6164744 | 0.79 | CCNA2 (0.72) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6163398 | 0.79 | CCNA2 (1.00) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| Hydrochloric Acid SCHEMBL6164285 | 0.78 | CCNA2 (0.71) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6162861 | 0.71 | OPRM1 (0.65) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6166973 | 0.66 | CCNA2 (0.73) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6165103 | 0.65 | CCNA2 (1.00) | CCNA2CDK2CCNOCCNE1CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | claimed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | claimed |
| JP-2002544271-A | — | — | 2002-12-24 | — | — | JP | claimed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | claimed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | claimed |
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |