Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.61 |
| ▸ | CDK2 | P24941 | 6/20 | 0.61 |
| ▸ | CCNO | P22674 | 1/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164595 | 0.84 | CCNA2 (0.47) | OPRM1CCNA2CDK2CCNOCCNE1 | |
| SCHEMBL6167069 | 0.84 | CCNA2 (0.47) | OPRM1CCNA2CDK2CCNOCCNE1 | |
| SCHEMBL6162155 | 0.83 | OPRM1 (0.57) | OPRM1CCNA2CDK2CCNOCCNE1 | |
| SCHEMBL6167358 | 0.82 | ALDH1A1 (0.57) | OPRM1CCNA2CDK2CCNOCCNE1 | |
| SCHEMBL6164588 | 0.81 | LMNA (0.70) | OPRM1CCNA2CDK2CCNOCCNE1 | |
| SCHEMBL6164586 | 0.81 | LMNA (0.70) | OPRM1CCNA2CDK2CCNOCCNE1 | |
| SCHEMBL6166305 | 0.81 | OPRM1 (0.76) | OPRM1ALDH1A1SMN1; SMN2OPRK1OPRD1 | |
| SCHEMBL6164703 | 0.81 | OPRM1 (0.45) | OPRM1CCNA2CDK2CCNOCCNE1 | |
| SCHEMBL6167242 | 0.80 | ALDH1A1 (0.62) | OPRM1CCNA2CDK2CCNOCCNE1 | |
| SCHEMBL6164944 | 0.77 | CCNA2 (0.62) | CCNA2CDK2CCNOCCNE1CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | claimed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | claimed |
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |