Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 18/20 | 0.73 |
| ▸ | CDK2 | P24941 | 18/20 | 0.73 |
| ▸ | CCNO | P22674 | 3/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166305 | 0.73 | OPRM1 (0.76) | MEN1ALDH1A1KMT2ASMN1; SMN2OPRM1 | |
| SCHEMBL6164565 | 0.68 | CCNA2 (1.00) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6164739 | 0.68 | CCNA2 (1.00) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6165208 | 0.68 | CCNA2 (1.00) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6164744 | 0.67 | CCNA2 (0.72) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6163398 | 0.67 | CCNA2 (1.00) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6163976 | 0.66 | CCNA2 (0.67) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6772430 | 0.66 | CCNA2 (0.44) | CCNA2CDK2CCNOCCNE1CCNA1 | |
| SCHEMBL6162529 | 0.65 | OPRM1 (0.56) | CCNA2CDK2MEN1ALDH1A1KMT2A | |
| SCHEMBL6167870 | 0.65 | ALDH1A1 (0.49) | CCNA2CDK2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |