Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 5/20 | 0.35 |
| ▸ | TRAP1 | Q12931 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501751 | 0.87 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA | |
| SCHEMBL6164112 | 0.82 | EDNRA (0.49) | ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA | |
| SCHEMBL7505827 | 0.82 | HSP90AA1 (0.39) | ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA | |
| SCHEMBL6577515 | 0.81 | KDM4E (0.39) | ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA | |
| SCHEMBL6160770 | 0.79 | HSP90AA1 (0.38) | ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA | |
| SCHEMBL3838481 | 0.76 | HSP90AA1 (0.37) | ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA | |
| SCHEMBL6579996 | 0.75 | HSP90AA1 (0.38) | ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA | |
| SCHEMBL27462057 | 0.75 | HSP90AA1 (0.39) | ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA | |
| SCHEMBL3834411 | 0.74 | HSP90AA1 (0.42) | ALDH1A1SMN1; SMN2KDM4EHPGDEDNRA | |
| SCHEMBL27462058 | 0.72 | TP53 (0.43) | ALDH1A1SMN1; SMN2KDM4EHPGDHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776325-B1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-11-20 | — | — | EP | disclosed |
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |
| EP-0776325-A1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1997-06-04 | — | — | EP | disclosed |
| WO-1996004276-A1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1996-02-15 | — | — | WO | disclosed |