SCHEMBL6164444

SCHEMBL6164444

O=C1C=Cc2ccccc2C1(Cl)Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 1/20 0.41
CACNB4 O00305 1/20 0.41
CACNA1A O00555 1/20 0.41
CACNA1G O43497 1/20 0.41
CACNG3 O60359 1/20 0.41
CACNA1F O60840 1/20 0.41
CACNA1H O95180 1/20 0.41
CACNB3 P54284 1/20 0.41
CACNA2D1 P54289 1/20 0.41
CACNG7 P62955 1/20 0.41
CACNA1B Q00975 1/20 0.41
CACNA1D Q01668 1/20 0.41
CACNB1 Q02641 1/20 0.41
CACNG1 Q06432 1/20 0.41
CACNB2 Q08289 1/20 0.41
CACNA1S Q13698 1/20 0.41
CACNA1C Q13936 1/20 0.41
CACNA1E Q15878 1/20 0.41
CACNA2D4 Q7Z3S7 1/20 0.41
CACNA2D3 Q8IZS8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2826156 0.84 MAPT (0.42) S100A4CACNB4CACNA1ACACNA1GCACNG3
SCHEMBL1651970 0.84 MAPT (0.42) S100A4CACNB4CACNA1ACACNA1GCACNG3
SCHEMBL1143283 0.74 MAPT (0.34) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL4235643 0.74 PDK2 (0.41) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL14293791 0.74 KDM4E (0.40) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL22744647 0.71 P2RX4 (0.39) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL11845488 0.71 KDM4E (0.38) MAPTKDM4EPKMMEN1ALDH1A1
SCHEMBL8461309 0.71 KDM4E (0.41) MAPTGAAKDM4EPKMMEN1
SCHEMBL3895348 0.68 THRB (0.50) MAPTKDM4EPKMMEN1ALDH1A1
SCHEMBL2408108 0.68 KIF11 (0.38) MAPTKDM4EPKMMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0713486-B1 PHOTOCHROMIC NAPHTHO(2,1-B)PYRANS PILKINGTON PLC (GB) 2002-07-17 EP claimed
EP-0691965-B1 PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS PILKINGTON PLC (GB) 1996-12-04 EP claimed
EP-0691965-A1 PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS PILKINGTON PLC (GB) 1996-01-17 EP claimed
WO-1994022850-A1 PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS PILKINGTON PLC (GB) 1994-10-13 WO claimed
EP-3367143-B1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL INC (US) 2023-01-11 EP disclosed
EP-2333028-B1 Photochromic compounds TRANSITIONS OPTICAL INC (US) 2017-11-08 EP disclosed
EP-1559713-B1 Chromene compound TOKUYAMA CORP (JP) 2014-09-24 EP disclosed
US-8582192-B2 Polarizing photochromic articles TRANSITIONS OPTICAL, INC. (US) 2013-11-12 US disclosed
US-8582192-B2 Polarizing photochromic articles TRANSITIONS OPTICAL, INC. (US) 2013-11-12 US disclosed
US-20110279883-A1 POLARIZING PHOTOCHROMIC ARTICLES TRANSITIONS OPTICAL, INC. (US) 2011-11-17 US disclosed
US-20110279883-A1 POLARIZING PHOTOCHROMIC ARTICLES TRANSITIONS OPTICAL, INC. (US) 2011-11-17 US disclosed
EP-2360224-A1 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2011-08-24 EP disclosed
EP-0875509-A1 Chromene compound TOKUYAMA CORPORATION (JP) 1998-11-04 EP disclosed
US-5623005-A NAPTHOPYRAN COMPOUNDS CONTAINING AMINE SUBSTITUTION AT 6-POSITION; USEFUL TO MAKE OPHTHALMIC LENS PILKINGTON PLC (GB) 1997-04-22 US disclosed
EP-0691965-B1 PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS PILKINGTON PLC (GB) 1996-12-04 EP disclosed
EP-0713486-A1 PHOTOCHROMIC NAPHTHO(2,1-B)PYRANS PILKINGTON PLC (GB) 1996-05-29 EP disclosed
US-5520853-A LIGHT SENSITIVE COMPOUNDS FOR POLYMERS OR CELLULOSE DERIVATIVES FOR LENSES PILKINGTON PLC (GB) 1996-05-28 US disclosed
EP-0691965-A1 PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS PILKINGTON PLC (GB) 1996-01-17 EP disclosed
WO-1995005371-A1 PHOTOCHROMIC NAPHTHO(2,1-B)PYRANS PILKINGTON PLC (GB) 1995-02-23 WO disclosed
WO-1994022850-A1 PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS PILKINGTON PLC (GB) 1994-10-13 WO disclosed