SCHEMBL6164692

SCHEMBL6164692

CC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](COCc2ccccc2)NC(=O)C(C)(C)NC(=O)OC(C)(C)C)CC1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 3/20 0.48
PPARA Q07869 2/20 0.46
CTSS P25774 1/20 0.44
UGCG Q16739 2/20 0.44
CYP3A4 P08684 1/20 0.44
PPARG P37231 1/20 0.43
TSHR P16473 2/20 0.41
ALOX15 P16050 1/20 0.41
ATM Q13315 1/20 0.41
KLK7 P49862 2/20 0.41
KLK5 Q9Y337 2/20 0.41
TACR1 P25103 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6164689 1.00 GHSR (0.48) GHSRPPARACTSSUGCGCYP3A4
SCHEMBL6163155 0.90 GHSR (0.46) GHSRPPARACTSSUGCGCYP3A4
SCHEMBL6164012 0.89 GHSR (0.45) GHSRPPARACTSSUGCGCYP3A4
SCHEMBL6164007 0.89 GHSR (0.45) GHSRPPARACTSSUGCGCYP3A4
SCHEMBL6162874 0.88 GHSR (0.48) GHSRPPARACTSSUGCGCYP3A4
SCHEMBL6162877 0.87 GHSR (0.46) GHSRPPARACTSSUGCGCYP3A4
SCHEMBL6162851 0.86 GHSR (0.62) GHSRUGCGCYP3A4TACR1
SCHEMBL6162855 0.86 GHSR (0.62) GHSRUGCGCYP3A4TACR1
Hydrochloric Acid SCHEMBL6163148 0.85 GHSR (0.62) GHSRUGCGCYP3A4TACR1
Hydrochloric Acid SCHEMBL6164166 0.85 GHSR (0.62) GHSRUGCGCYP3A4TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828754-B1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER (US) 2005-02-02 EP disclosed
EP-0828754-A1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER INC. (US) 1998-03-18 EP disclosed
WO-1996038471-A1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER INC. (US) 1996-12-05 WO disclosed
WO-1996035713-A1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER, INC. (US) 1996-11-14 WO disclosed