Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771820 | 0.83 | OPRM1 (0.75) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL6163702 | 0.82 | OPRM1 (0.62) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL6166305 | 0.81 | OPRM1 (0.76) | OPRM1SMN1; SMN2OPRK1OPRD1 | |
| SCHEMBL21558166 | 0.75 | OPRM1 (0.66) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL13790196 | 0.75 | OPRM1 (0.73) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL21558179 | 0.74 | OPRM1 (0.65) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL6770719 | 0.74 | OPRM1 (0.76) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL16883487 | 0.73 | OPRM1 (0.62) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL6770401 | 0.72 | OPRM1 (0.77) | OPRM1HSP90AB1OPRK1OPRD1 | |
| SCHEMBL15613351 | 0.72 | HSP90AB1 (0.67) | OPRM1HSP90AB1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | claimed |
| JP-2002544271-A | — | — | 2002-12-24 | — | — | JP | claimed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | claimed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | claimed |
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |