Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 17/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770719 | 0.86 | OPRM1 (0.76) | OPRM1OPRK1OPRD1 | |
| SCHEMBL1220991 | 0.85 | OPRM1 (0.77) | OPRM1LMNATSHRKMT2AHTT | |
| SCHEMBL6771820 | 0.85 | OPRM1 (0.75) | OPRM1OPRK1OPRD1 | |
| SCHEMBL6772954 | 0.84 | OPRM1 (0.78) | OPRM1OPRK1OPRD1 | |
| SCHEMBL6163702 | 0.84 | OPRM1 (0.62) | OPRM1OPRK1OPRD1 | |
| SCHEMBL6770401 | 0.84 | OPRM1 (0.77) | OPRM1LMNATSHRHTTHSD17B10 | |
| SCHEMBL6162637 | 0.82 | OPRM1 (0.63) | OPRM1LMNATSHRKMT2AHTT | |
| SCHEMBL6165217 | 0.82 | OPRM1 (0.53) | OPRM1LMNATSHRKMT2AHTT | |
| SCHEMBL6168169 | 0.82 | OPRM1 (0.53) | OPRM1LMNATSHRKMT2AHTT | |
| SCHEMBL1220925 | 0.82 | OPRM1 (0.75) | OPRM1KMT2AHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344997-B1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | UNIV MINNESOTA (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |