Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.77 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767006 | 0.87 | OPRM1 (0.58) | OPRM1OPRK1OPRD1HSP90AB1 | |
| SCHEMBL6770719 | 0.84 | OPRM1 (0.76) | OPRM1OPRK1OPRD1HSP90AB1 | |
| SCHEMBL6770500 | 0.84 | OPRM1 (0.61) | OPRM1OPRK1OPRD1HSP90AB1 | |
| SCHEMBL6166305 | 0.84 | OPRM1 (0.76) | OPRM1OPRK1OPRD1ALDH1A1LMNA | |
| SCHEMBL7479730 | 0.83 | OPRM1 (0.54) | OPRM1OPRK1OPRD1HSP90AB1ALDH1A1 | |
| SCHEMBL7537151 | 0.83 | OPRM1 (0.54) | OPRM1ALDH1A1LMNATP53ALOX15 | |
| SCHEMBL6772068 | 0.82 | ALDH1A1 (0.57) | OPRM1OPRK1OPRD1HSP90AB1ALDH1A1 | |
| SCHEMBL1220991 | 0.81 | OPRM1 (0.77) | OPRM1OPRK1OPRD1HSP90AB1LMNA | |
| SCHEMBL6771990 | 0.80 | OPRM1 (0.54) | OPRM1ALDH1A1LMNAHTTNPSR1 | |
| SCHEMBL1220925 | 0.80 | OPRM1 (0.75) | OPRM1HSP90AB1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |