Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164169 | 0.82 | HTT (0.48) | HTTKMT2AHSD17B10PTGIRSMN1; SMN2 | |
| SCHEMBL6162358 | 0.81 | HTT (0.46) | HTTKMT2AALDH1A1MAPTGAA | |
| SCHEMBL6166822 | 0.71 | HTT (0.44) | HTTKMT2ABRD4ALDH1A1MAPT | |
| SCHEMBL6166715 | 0.69 | KCNK3 (0.39) | HTTKCNK3KMT2AMAPK1BRD4 | |
| SCHEMBL6167324 | 0.69 | BRD4 (0.38) | HTTKCNK3KMT2AMAPK1BRD4 | |
| SCHEMBL11166069 | 0.67 | L3MBTL1 (0.46) | KMT2AMAPK1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6164117 | 0.65 | HTT (0.46) | HTTKMT2ATSHRLMNAMAPT | |
| SCHEMBL16193457 | 0.64 | BRD4 (0.48) | KMT2AMAPK1BRD4LMNANPC1 | |
| SCHEMBL3937799 | 0.64 | KMT2A (0.63) | HTTKMT2APTGIRSMN1; SMN2ALDH1A1 | |
| SCHEMBL7480329 | 0.64 | HRH2 (0.46) | HTTKMT2AMAPK1BRD4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |