Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165983 | 0.84 | ATM (0.44) | KDM4EBRD4CREBBPALDH1A1KMT2A | |
| SCHEMBL6164169 | 0.82 | HTT (0.48) | HTTKDM4ECREBBPALDH1A1KMT2A | |
| SCHEMBL6167339 | 0.76 | HTT (0.45) | HTTKDM4EALDH1A1KMT2AGAA | |
| SCHEMBL6166050 | 0.75 | HTT (0.47) | HTTALDH1A1 | |
| SCHEMBL6161914 | 0.75 | HTT (0.44) | HTTKDM4EALDH1A1KMT2AGAA | |
| SCHEMBL6164980 | 0.75 | HTT (0.44) | HTT | |
| SCHEMBL6162358 | 0.74 | HTT (0.46) | HTTKDM4ECREBBPALDH1A1KMT2A | |
| SCHEMBL6164630 | 0.74 | HTT (0.41) | HTTKDM4EALDH1A1KMT2AGAA | |
| SCHEMBL6164117 | 0.72 | HTT (0.46) | HTTKMT2AHRH3MEN1MAPT | |
| SCHEMBL6164255 | 0.72 | HTT (0.46) | HTTKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |