Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | PEX14 | O75381 | 5/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164169 | 0.78 | HTT (0.48) | HTTKDM4EALDH1A1CREBBPMEN1 | |
| SCHEMBL6166822 | 0.74 | HTT (0.44) | HTTKDM4EALDH1A1GAACREBBP | |
| SCHEMBL6164980 | 0.72 | HTT (0.44) | HTT | |
| SCHEMBL6166773 | 0.66 | HTT (0.52) | HTT | |
| SCHEMBL6166178 | 0.66 | SIK2 (0.33) | ALDH1A1GAAHTR2CMAPTCA1 | |
| SCHEMBL6166246 | 0.65 | HTT (0.42) | HTTKDM4EMEN1KMT2A | |
| SCHEMBL6166242 | 0.65 | HTT (0.42) | HTTKDM4EMEN1KMT2A | |
| SCHEMBL8736314 | 0.64 | ALDH1A1 (0.56) | HTTPOLLKDM4EALDH1A1GLA | |
| SCHEMBL266254 | 0.64 | KDM4E (0.56) | POLLKDM4EALDH1A1GLAGAA | |
| SCHEMBL6165167 | 0.64 | HTT (1.00) | HTTALDH1A1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |