Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.60 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | DPP4 | P27487 | 3/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.51 |
| ▸ | FAP | Q12884 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145714 | 0.87 | DPP4 (0.57) | OPRD1SMYD3DPP4DPP8DPP9 | |
| SCHEMBL7360693 | 0.85 | HPGD (0.66) | OPRD1SMYD3HDAC8POLBDPP4 | |
| SCHEMBL6161830 | 0.83 | OPRD1 (0.65) | OPRD1SMYD3HDAC8POLBDPP4 | |
| SCHEMBL3133533 | 0.83 | OPRD1 (0.65) | OPRD1SMYD3HDAC8POLBDPP4 | |
| SCHEMBL6705226 | 0.83 | HDAC8 (0.56) | OPRD1SMYD3HDAC8ROCK2CYP3A4 | |
| Hydrochloric Acid SCHEMBL6165745 | 0.82 | HDAC8 (0.63) | OPRD1SMYD3HDAC8POLBDPP4 | |
| Hydrochloric Acid SCHEMBL6163301 | 0.82 | HDAC8 (0.63) | OPRD1SMYD3HDAC8POLBDPP4 | |
| Hydrochloric Acid SCHEMBL6163295 | 0.82 | HDAC8 (0.63) | OPRD1SMYD3HDAC8POLBDPP4 | |
| SCHEMBL4969587 | 0.82 | SMYD3 (0.61) | OPRD1SMYD3HDAC8ROCK2CYP3A4 | |
| SCHEMBL5891540 | 0.82 | HDAC8 (0.60) | OPRD1HDAC8ROCK2CYP3A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |