Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8595853 | 0.79 | NPC1 (0.42) | HTR2AHTR2CHTR2BPOLBTAAR1 | |
| SCHEMBL7681450 | 0.78 | TAAR1 (0.40) | HTR2AHTR2CHTR2BTAAR1SLC6A4 | |
| SCHEMBL8598453 | 0.77 | NPC1 (0.42) | HTR2AHTR2CHTR2BPOLBTAAR1 | |
| SCHEMBL7681468 | 0.76 | CREBBP (0.42) | TAAR1 | |
| SCHEMBL7681583 | 0.76 | TAAR1 (0.40) | HTR2AHTR2CHTR2BTAAR1HTR1A | |
| SCHEMBL8670994 | 0.76 | TDP1 (0.42) | HTR2AHTR2CHTR2BTAAR1HTR1A | |
| SCHEMBL8597121 | 0.74 | NPC1 (0.43) | HTR2AHTR2CHTR2BPOLBTAAR1 | |
| SCHEMBL7679337 | 0.74 | CREBBP (0.42) | TAAR1 | |
| SCHEMBL8948110 | 0.74 | HTR1A (0.46) | HTR2AHTR2CTAAR1HTR1ATDP1 | |
| SCHEMBL8597148 | 0.74 | NPC1 (0.36) | HTR2AHTR2CHTR2BTAAR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060163-B1 | NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES | KLINGE CO CHEM PHARM FAB (DE) | 2005-10-12 | — | — | EP | disclosed |
| US-6903118-B1 | Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides | KLINGE PHARMA GMBH (DE) | 2005-06-07 | — | — | US | disclosed |