Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.46 |
| ▸ | HTR2C | P28335 | 7/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | IDE | P14735 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947998 | 0.74 | HTR2A (0.46) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL6164922 | 0.74 | HTR2A (0.45) | HTR1AHTR2CDRD2HTR2ATDP1 | |
| SCHEMBL8948107 | 0.74 | HTR1A (0.73) | HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL8595853 | 0.71 | NPC1 (0.42) | HTR2CHTR2ATDP1TAAR1SIGMAR1 | |
| SCHEMBL5678869 | 0.70 | HTR1A (0.40) | HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL7681450 | 0.70 | TAAR1 (0.40) | HTR2CDRD2HTR2ATDP1TAAR1 | |
| SCHEMBL8598453 | 0.69 | NPC1 (0.42) | HTR2CHTR2ATDP1TAAR1 | |
| SCHEMBL4891426 | 0.69 | HTR1A (0.75) | HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL7681468 | 0.69 | CREBBP (0.42) | TAAR1SIGMAR1 | |
| SCHEMBL8597148 | 0.68 | NPC1 (0.36) | HTR2CHTR2ATDP1TAAR1IDE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |