Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 7/20 | 0.40 |
| ▸ | FNTB | P49356 | 7/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722582 | 0.91 | NPC1 (0.37) | BRD4CREBBPFNTAFNTBMDM2 | |
| SCHEMBL4435324 | 0.85 | ALDH1A1 (0.35) | BRD4CREBBPFNTAFNTBMDM2 | |
| SCHEMBL12590536 | 0.85 | FNTA (0.42) | BRD4CREBBPFNTAFNTB | |
| SCHEMBL30419724 | 0.82 | FNTA (0.56) | FNTAFNTB | |
| SCHEMBL1538260 | 0.82 | FNTA (0.56) | FNTAFNTB | |
| SCHEMBL6861981 | 0.81 | ALDH1A1 (0.42) | FNTAFNTB | |
| SCHEMBL5657960 | 0.75 | FNTA (0.48) | FNTAFNTB | |
| SCHEMBL6165529 | 0.74 | FNTA (0.78) | FNTAFNTB | |
| SCHEMBL6866186 | 0.74 | FNTA (0.47) | FNTAFNTB | |
| SCHEMBL6163338 | 0.74 | FNTA (0.58) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107962-B1 | QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PROD INC (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6495564-B1 | SUCH AS 3-(6-((4-CHLORO-PHENYL)-HYDROXY-(3-METHYL-3H-IMIDAZOL-4-YL)-METHYL)-1-METHYL-2-OXO-1,2-DIHYDRO-QUINOLIN-4-YL)-BENZALDEHYDE O-METHYL-OXIME; INHIBITING ABNORMAL CELL GROWTH | PFIZER INC. | 2002-12-17 | — | — | US | disclosed |
| EP-1107962-A1 | QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012498-A1 | QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-03-09 | — | — | WO | disclosed |