Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.55 |
| ▸ | RAF1 | P04049 | 6/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162134 | 0.85 | MAPK14 (0.52) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6164609 | 0.83 | MAPK14 (0.53) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6165061 | 0.81 | MAPK14 (0.51) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6161474 | 0.79 | MAPK14 (0.63) | MAPK14RAF1MAPK12FLT1KDR | |
| SCHEMBL6167100 | 0.76 | RAF1 (0.57) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6163117 | 0.75 | RAF1 (0.56) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6164616 | 0.74 | MAPK14 (0.58) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6163413 | 0.74 | MAPK14 (0.53) | MAPK14RAF1MAPK12FLT1KDR | |
| SCHEMBL6162064 | 0.73 | MAPK14 (0.52) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL3242753 | 0.71 | MAPK14 (1.00) | MAPK14RAF1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6476023-B1 | Aromatic heterocyclic compounds as anti-inflammatory agents | BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |
| US-6297381-B1 | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | disclosed |