Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7169246 | 0.87 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 | |
| SCHEMBL31059889 | 0.87 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 | |
| SCHEMBL28335219 | 0.85 | LOXL2 (0.67) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 | |
| SCHEMBL3663173 | 0.84 | LOXL2 (0.60) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 | |
| SCHEMBL1854449 | 0.83 | LOXL2 (0.64) | LOXL2HRH3MTNR1AMTNR1BIDO1 | |
| SCHEMBL6860219 | 0.83 | LOXL2 (0.64) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 | |
| SCHEMBL29403791 | 0.83 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BAHR | |
| SCHEMBL28338445 | 0.83 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BAHR | |
| SCHEMBL401081 | 0.83 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BAHR | |
| SCHEMBL2261199 | 0.80 | LOXL2 (0.60) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939632-B1 | NON-PEPTIDYL VASOPRESSIN V1a ANTAGONISTS | LILLY CO ELI (US) | 2005-10-05 | — | — | EP | disclosed |
| US-6610680-B1 | Administering as adjuncts in heart failure or as antithrombotic agents, treatment of obsessive-compulsive disorder, aggressive disorders, depression and anxiety | ELI LILLY AND COMPANY | 2003-08-26 | — | — | US | disclosed |
| US-6521611-B2 | 2-(azetidin-2-on-1-yl) acetic acid derivatives; treatment of obsessive-compulsive disorder | ELI LILLY AND COMPANY | 2003-02-18 | — | — | US | disclosed |
| EP-0939632-A4 | NON-PEPTIDYL VASOPRESSIN V1a ANTAGONISTS | LILLY CO ELI (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6340681-B1 | USEFUL AS ANALGESICS IN MAMMALS | PFIZER INC | 2002-01-22 | — | — | US | disclosed |
| US-6204260-B1 | 2-(AZETIDIN-2-ON-1-YL)ACETIC ACID DERIVATIVES | ELI LILLY AND COMPANY | 2001-03-20 | — | — | US | disclosed |
| EP-0939632-A1 | NON-PEPTIDYL VASOPRESSIN V1a ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1997030707-A1 | NON-PEPTIDYL VASOPRESSIN V1a ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |
| US-4104371-A | Psychopharmacologically active peptides and peptide-derivatives, and the use thereof | AKZONA INCORPORATED (US) | 1978-08-01 | — | — | US | disclosed |