Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GALK1 | P51570 | 3/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.36 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | IL6 | P05231 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167218 | 0.91 | ITGA4 (0.41) | HSD17B10GALK1ITGA4ITGB1MEN1 | |
| SCHEMBL6168715 | 0.91 | LMNA (0.34) | GALK1ITGA4LMNAPOLBIL6 | |
| SCHEMBL6165328 | 0.89 | HSD17B10 (0.41) | HSD17B10GALK1ITGA4ITGB1MEN1 | |
| SCHEMBL6164091 | 0.89 | HSD17B10 (0.41) | HSD17B10GALK1ITGA4ITGB1MEN1 | |
| SCHEMBL6165451 | 0.86 | KMT2A (0.42) | HSD17B10GALK1ITGA4ITGB1RIOK2 | |
| SCHEMBL6161852 | 0.86 | ITGA4 (0.42) | GALK1ITGA4ITGB1MEN1KMT2A | |
| SCHEMBL6164820 | 0.86 | ITGA4 (0.47) | GALK1ITGA4ITGB1LMNAPOLB | |
| SCHEMBL6170579 | 0.85 | ITGB3 (0.39) | HSD17B10GALK1ITGA4ITGB1POLB | |
| SCHEMBL6165024 | 0.85 | GALK1 (0.44) | GALK1ITGA4ITGB1CSNK1DMAPT | |
| SCHEMBL6165027 | 0.85 | GALK1 (0.44) | GALK1ITGA4ITGB1CSNK1DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183254-B1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS INTEGRIN ANTAGONISTS | AVENTIS PHARMA LTD (GB) | 2005-01-12 | — | — | EP | disclosed |
| EP-1183254-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS INTEGRIN ANTAGONISTS | Aventis Pharma Limited (GB) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000061580-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS INTEGRIN ANTAGONISTS | AVENTIS PHARMA LIMITED (GB) | 2000-10-19 | — | — | WO | disclosed |